PTX100R UART without hardware flow control

I have implemented the PTX100R onto a board and can't use hardware flow control because I don't have the pins from the host board. I can see there are some settings in the OS host SDK to enable / disable hardware flow control but before I keep going with this device, I really need to know if hardware flow control is essential or if no hardware flow control is acceptable or maybe software flow control.  Please help!

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